Press Filtration Cell Disruption 6. Candle Filtration 1. Homogenization 7. Flotation 2. Bead Milling 3. Osmotic Shock Product Extraction By 1. Organic Solvents 2. Centrifugation 4. Supercritical Fluids 2. Microfiltration 5. Adsorption 3. Vacuum Filtration 6. Reverse Micelles 4. Press Filtration 7. Distillation Concentration 1. Ultrafiltration Denatured Products 2. Evaporation Renaturation 3.
Where is biopharmaceutical manufacturing heading? BioPharm Int. Pais-Chanfrau J, et al. The impact of disposables on project economics in a new antibody plant: a case study. Implementing a fully disposable mAb manufacturing facility. BioProcess Int. Systematic evaluation of single-use systems using process simulation tools. Single-use technology and modular construction.
The therapeutic monoclonal antibody market. Kelley B. Very large scale monoclonal antibody purification: the case for conventional unit operations. Biotechnol Prog. PubMed Google Scholar. Intelligen Inc. Scotch Plains USA 2. Personalised recommendations. After 3. Fermentation biomass concentration and toxicity were based on experimental data from Liu et al. Fermentation operations per se comprise Section of The biomass and spore concentration results of Arcas et al.
Broth and product potency is are also shown since these workers obtained the expressed in billions of international units per unit highest reported Bt biomass concentration of As the figure shows, the latter group The fermentor, operating cycle of 66 h was assumed to achieved biomass concentrations as high as The fed- as follows: sterilization and checks: 1.
It was also designed to produce a B. Detailed formulation compositions were taken from Lisansky et al. The formulation ingre- dients used are shown in the list of raw material usage and. Figure 2. Viable spore concentration results from [10] 5,n and o, , costs for the base case given in Table II. Open and closed symbols represent batch and fed-batch fermentation results, respectively.
Economic Analysis Calculation Methods Economic analysis was performed in Canadian dollars for a higher spore concentrations are achievable for a given bio- stand-alone plant located in southern Ontario, Canada, using mass concentration.
They also showed that nutrient feeding methods given in Ulrich unless noted. This price was chosen based fermentations of Liu et al. The data of runs other formulation types. The issue of production scale is 6 and 7 of these authors for the two fed-batch cases discussed below.
These three equipment size, number of identical units and installed cost, fermentation process configurations are designated hence- total capital investment, operating costs, revenue, and over- forth as batch, low-density fed-batch LDFB , and high- all profitability. The calculation procedures used are des- density fed-batch HDFB processes, respectively.
Product recovery, formulation and packaging comprise Equipment costs were in general derived from Ulrich Sections and of the process Fig. It was designed to size from which the equations of linear segments of the produce three B. Installed cost for each piece of process equipment cf. Table I was obtained by multiplying pur- Installed Equipment and Total Capital Cost chase cost by an installation cost factor which varies with the type of unit, construction material, etc.
The installation cost Table I presents a listing of plant equipment, and total capi- factor accounts for transportation of the equipment to the tal cost and power requirements, for base case production at site, direct materials e. For a stand-alone plant, total etc. All equipment in contact cost. The distribution of installed equipment cost. The with aqueous process liquids was costed on the basis of distribution of installed equipment cost among process stainless steel.
The cumulative figure resulting from this procedure was the total base bare module capital Usage and costs for raw materials for the base case are required for the plant. This type of material costs. It is seen that production cost ment cost was multiplied by 1. Finally, working capital for raw materials and supplies, finished and semifinished Table III.
Manufacturing cost analysis for base case production scenario product, etc. Table III, Raw materials 1, Raw materials usage and costs were summed; Administrative labor Detailed trial calculations Overhead and storage Total annual costs and profitability were calculated Depreciation year plant write-off 1, Accepted wisdom in this regard is commonly known as the six-tenths-factor rule, viz.
The capital- dependent operating cost data for the two scales presented by Lisansky et al. For the LDFB configuration of the present analysis with scale in the range 0.
It appears warranted to conclude that the present capital cost estimates are considerably more realistic than those of Lisansky et al. The output from a detailed manufacturing cost analysis for the base case is shown in Table III. Utilities as a group com- prise the largest cost component, followed in decreasing Figure 3.
Total per-unit production cost vs. The lowest overall opera- scale of operations is increased. It is also seen that increasing ting costs regardless of scale occurred for the high-density fermentation broth potency from 0. Conversely, the scale, with the category showing the largest reduction break-even point for the batch fermentation case, occurs at a depending on the fermentation process configuration.
This plot also shows for batch fermentation by far the largest reduction was for that for the fed-batch cases the actual selling price will have a capital-dependent items, followed by labor-dependent items, relatively strong effect on the scale at which the break-even administration and overhead, and utilities.
In the fed-batch point is reached. View 2 excerpts, cites methods. Marcel P. View 2 excerpts, cites background. Bioreactor control systems in the biopharmaceutical industry: a critical perspective. Systems Microbiology and Biomanufacturing. Industrial-scale bioprocessing underpins much of the production of pharmaceuticals, nutraceuticals, food, and beverage processing industries of the modern world.
The profitability of these processes … Expand. Empirical analysis of large-scale bio-succinic acid commercialization from a technoeconomic and innovation value chain perspective: BioAmber biorefinery case study in Canada.
Green solvents in the biotechnology-based pharmaceutical industry. Lipid microencapsulation process using spray drying: modeling and heat recovery study.
Brazilian Journal of Chemical Engineering. Spray drying microencapsulation is the most recommended technique for functional ingredients preservation and has many technological applications. However, this process consumes high amounts of … Expand. View 1 excerpt, cites methods.
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